Therapeutic eye drops

EACE (Eye Amniotic Cytokine Extract)

EACE therapeutic eye drops are used to treat diseases and wounds of the scleral area of the eye and cornea. This is done through stimulation and proliferation of corneal stem cells. The most important active ingredient of this product is amniotic membrane extract and it contains growth factors and important cytokines for wound healing, neutrophils and interleukin antagonists, in addition to fibronectin and collagen, glycoproteins and glycosaminoglycans, which can be effective in treating wounds without causing scars and keloids. The growth factors present in the product by affecting the fibroblast cells in the target area cause their proliferation and the secretion of extracellular matrix and facilitate cell migration. Other features of the amniotic membrane include low immunogenicity and antigenicity, prevention of keloids and scar tissue formation, quick attachment to the wound surface and facilitation of cell differentiation and attachment, induction and facilitation of cell migration, reduction of inflammation and pain in the area, creation of a homogeneous substrate for tissue regrowth, reduction From the possibility of tumor regrowth, no risk of graft rejection, no local and systemic toxicity, prevention of bacterial proliferation on the surface of the product are prominent features. which is used in the eye product.

Eye drops stimulate and multiply corneal stem cells and accelerate the healing of the corneal epithelium without any side effects and can be used as a supplement in corneal cell therapy. amniotic membrane are also effective for improving the growth of limbal stem cells after transplantation.
The eye drops that are the result of biotechnological processes on the amnion membrane have many therapeutic uses that can be used in the treatment of wounds and surface lesions of the eye, corneal tissue reconstruction, and eye surgeries. This product is widely used in corneal lesions such as neurotrophic wounds, permanent epithelioma defects, treatment of all types of keratitis, chemical burns, reconstruction of the eye surface and also in conjunctival pathologies such as removal of SCC squamous cell carcinoma of the conjunctiva, pterygium and correction of symblepharon. Life Cell eye drops have the ability to reduce scars, stimulate wound healing and restore the epithelium, and because of its anti-bacterial properties, it is of special therapeutic importance in the scleral area of ​​the eye.

These applications include:
* Treatment of pterygium or trigeminal
* Removal of permanent epithelioma defect and neurotrophic ulcer
* Ulcers shield treatment
* Treatment of infectious keratitis
* Treatment of Bollous Keratopathy
* Keratopathy Band treatment
* PRK photorefractive keratectomy and phototherapeutic keratectomy
* Treatment of chemical injuries
* Reconstruction of conjunctival surfaces
* Fixing and treating the relative deficiency of limbus stem cells
* Corneal transplantation following stem cell transplantation
* Filtering bulb
* Cicatricial entropion

Product catalog


Eye drops treatment mechanism

The effectiveness of the eye drop product depends on several mechanisms:

  1. Production of growth factors and cytokines and acceleration of epithelialization
  2. Antimicrobial and antiviral properties and therefore reduce infection in the site
  3. Anti-inflammatory property by inhibiting cells and inflammatory factors and their protease activity (anti- scar and anti-inflammatory)
  4. Inhibiting inflammation and not causing immunological reactions
  5. Biomechanical properties and tissue structure of collagen-rich basement membrane
  6. Reduce pain and wound infection
  7. Inhibition of myofibroblastic differentiation of normal fibroblasts and prevention of scar formation
  8. A suitable matrix for cell migration and proliferation
  9. It provides bio-barrier for tissues.
  10. Its processing is done according to international standards guidelines in completely sterile conditions and in clean rooms.

Benefits of using eye drops:

• Antimicrobial properties
• Reduction of wound scars, reduction of infection and tissue fibrosis
• Increasing the speed of epithelial tissue renewal
• Low costs compared to other biological dressings. By using this curtain to treat patients, the duration of hospitalization is reduced by about a third.
• Easy to use
• Absence of immunological reaction

Specifications of eye drops:

Amniotic membrane or amnion is the innermost layer of the placenta, whose thickness varies from 0.02 to 0.05 and consists of the following three layers.
layer of epithelial cells

Fibroblast growth factor (FGF)
Platelet derived growth factor (PDGF)
Epidermal growth factor (EGF)
Vascular endothelial growth factor (VEGF)

Thick basement membrane layer included

• Types of collagen V, VI, VIII, II, III, IV
• Types of bioactive factors secreted from the extracellular matrix (ECM), such as types of collagen, fibronectin, laminin, proteoglycan, and glycoaminoglycan, which lead to the stimulation of cell growth.

The stroma layer (mesenchymal tissue without vessels) includes:

• TGF-beta
• Anti-inflammatory factors
• Factors inhibiting proteases
• Stem cells: The stem cells on the amniotic membrane are mesenchymal cells. These cells are capable of differentiating into the tissue cells of the transplant site. The mesenchymal cells of the amnion membrane have the ability to differentiate into keratinocytes (skin epidermis), adipogenetic (fat- forming), chondrogenic (cartilage-forming), stenogenetic (bone-forming), angiogenic (vascular-forming), myogenetic (muscle-forming) cells.

The application of processed amnion membrane is as a biological dressing in skin surgeries and burns, eye defects, eye injuries, spinal cord, etc.

Production of eye drops from amniotic membrane:

For the preparation of the eye drop product, the amniotic membrane of the pairs of healthy mothers who undergo cesarean surgery is used. All the steps of working on the pair and processing the tissues are done in the class 100 laminar hood, which is located in the clean room environment. After processing the amnion, it is placed in special containers and stored at a temperature of -80 degrees by a controlled freezing method. This method is vital for maintaining the integrity of the tissue and its biological effects, and its superiority over other tissue preservation methods has been proven. It is possible to store amnion and its performance at -80 degrees for one year. It is also possible to store the final product in a normal freezer. Then, in a complex process, its extract is extracted under the name of eye drops.

Eye drop product quality control

Quality control of Life Cell products includes a complete wide network of donor screening and complete and accurate virology and serology tests, which are in accordance with the global standards set by eu-directive 23/2004. The tests include the following:
HIV 1,2 Ab / HCVAb / HBCAb / HBSAb / HBSAg
HTLV 1,2 Ab / RPR / Endotoxin / MYCOPLASMA