Lifescell tendon reconstruction product ( TNR

 

TNR is a highly reliable, stable and safe Tendon tissue reconstruction product . TNR is derived from the bio-nutrient and chemotactic factors of placental allograft which shows strong resemblance to the human Tendon tissue with regard to chemical composition, porosity


The pronounced viscosity of the TNR supports a fast uptake of patient comfort , thus improving applications. The unique manufacturing process based on biotechnology removes all organic and potentially antigenic components,making the material absolutely safe and free of discomfort


TNR is the leading material , as demonstrated by its clinical and scientific success


TNR product as a Tendon tissue reconstruction allograft is a effective compound of different part of placental allograft . it is extracted from placenta and enriched by biofactors of amniotic and chorionic membrane by the growth factors and cytokines and also viscose materials of embilical cord


TNR is a safe, reliable substitute with controlled resorption properties and excellent handling characteristics


TNR product as a biotechnologic compound is produced in applicable size as 3cc

TNR Product Mechanism of action

Innovative lifescell Tendon tissue regeneration has become the new standard for reconstruction healing and repair. The goal of tendon tissue regeneration is to reconstruct or repair and replace damaged or diseased tendon tissue with healthy tendon tissue that is fully functional by bioactive elements . Tendon tissue reconstruction is primarily composed of cells , extracellular matrixes and chemotactic factors like as growth factors and cytokines


Cells are the biological building blocks of tendon tissue. They maintain the function of the tendon tissue by synthesizing proteins or metabolizing waste. Single cells communicate with one another and respond to stimuli in their surrounding environments. Cells secrete and maintain extracellular matrix (ECM) which is the structural component of tendon tissues reconstruction


Cells interact with each other and the ECM through direct contact as well as soluble signaling molecules, including cytokines, growth factors, hormones, steroids, enzymes, and other chemicals. These signals stimulate a chain reaction or cascade which alters cell behavior, both in the releasing cell itself, as well as other neighboring cells of a tendon tissue


 

 

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Mechanism of action for TNR is relevant to The anti inflammatory bio actives to control of inflammatory parameters and also as a infra structure for cell immigration for reconstruction and healing which suggests support for local stem cells and transient amplifying local cells and promotes cell differentiation while excluding inflammatory cells and their protease activities


composition is reflected into the controlled resorption behavior of TNR, which results in an initial integration of the particles followed by a complete resorption. While the fast resorption of some factors continuously increases the porosity of the material promoting tendon tissue integration by allowing ingrowth of cells and blood vessels, the other component provides volume stability for an extended time period


composition is reflected into the controlled resorption behavior of TNR, which results in an initial integration of the particles followed by a complete resorption. While the fast resorption of some factors continuously increases the porosity of the material promoting tendon tissue integration by allowing ingrowth of cells and blood vessels, the other component provides volume stability for an extended time period


This action assists healing tendon tissue reconstruction, consist of different bioactive elements to make tendon tissue reconstruction in the body and including but not limited to following bioactive elements

Multiple bioactive factors: Stimulate growth, cell division, and accelerate the treatment and repair of various types of Tendon tissue defects *


:properties are

Extra Cellular Matrix (ECM) composed of proteoglycan, glycosaminoglycan, glycoprotein, collagen (I, III, IV, VI, VIII *

fibronectin, laminin, and elastin, and forms scaffolding to cover the tendon tissue reconstruction ,

Simulation and repair of lost tendon tissues due to the ability to differentiate and transform the immigrated stem cells *

including the tendon tissue of the transplantation place

Full biocompatibility and lack of of immunologic reactions due to the antigenicity and immunogenicity *

of the TNR as well as DNA Diminished during the complex preparation and production process

Induction and accelerated cellular migration at the local stages due to extracellular matrix *

, and an appropriate substrate for healing,

Lack of local and systemic poisoning due to the absence of toxic and TNRcinogenic substances *

Reduce inflammation due to inhibiting pro-inflammatory cytokines and inhibiting the activity

of local neutrophil chemokine, macrophages, and also inhibition of T cell and B cell proliferation and apoptosis

Reduce the risk of fibrosis *

Prevent excessive tendon tissue growth by stopping abnormal vascular growth *

TNR product Directions & Aplications

Reconstruction of damaged Tendon tissue -

Anti scar tendon wound healing -

 
Lifescell products Technology & immunity in production

The production line of Lifescell product is based on innovative PLACENTAL ALLOGRAFT tissue engineering regulated by biotechnology standards and protocols. After selecting the donor, firstly the medical history of the person is carefully assessed and screened with the priority of the diseases transmittable through the blood. All donor mothers are screened for chronic, infectious, neurological, autoimmune, malignant, and other environmental factors. (According to the AATB standard, these tests are repeated for the patient after the Window Period (NAT tests
Screening tests

HIV-1 & HIV-2 Antibody *

HIV Type 1 (Nucleic Acid Test *

HTLV-1 & HTLV-2 Antibody *

Hepatitis B Core Antibody *

Hepatitis B Surface Antigen *

Hepatitic C Antibody *

Hepatitic C Virus (Nucleic Acid Test *

CMV Total Antibody *

Syphilis (Serological Test *

 

(Lifescell TNR product COA ( Certificate of Analysis

Lifescell TNR product COA-1 (Copy)

The certificate of analysis data ie accredited by quality control department of lifescell biotechnology site and production line is in accordance with GMP articles and FDA regulation for good tendon tissue practices ( 21 CFR 1270,71) also in accordance to ministry of health regulations