Lifescell cartilage reconstruction product

(CAR)
rejuvenation

CAR is a highly reliable, stable and safe cartilage reconstruction product . CAR is derived from the bio-nutrient and mineral phase of placental allograft which shows strong resemblance to the human cartilage with regard to chemical composition, porosity . The pronounced viscosity of the CAR supports a fast uptake of patient comfort , thus improving applications. The unique manufacturing process based on biotechnology removes all organic and potentially antigenic components,making the material absolutely safe and free of discomfort. CAR is the leading material , as demonstrated by its clinical and scientific success. CAR product as a cartilage reconstruction allograft is a effective compound of different part of placental allograft . it is extracted from placenta and enriched by biofactors of amniotic and chorionic membrane by the growth factors and cytokines and also viscose materials of embilical cord . CAR is a safe, reliable substitute with controlled resorption properties and excellent handling characteristics. CAR product as a biotechnologic compound is produced in applicable size as 4cc syring

CAR Product Mechanism of action

Innovative lifescell Tissue regeneration has become the new standard for reconstruction healing and repair. The goal of tissue regeneration is to reconstruct or repair and replace damaged or diseased tissue with healthy tissue that is fully functional by bioactive elements . Tissue reconstruction is primarily composed of cells , extracellular matrixes and chemotactic factors like as growth factors and cytokines . Cells are the biological building blocks of tissue. They maintain the function of the tissue by synthesizing proteins or metabolizing waste. Single cells communicate with one another and respond to stimuli in their surrounding environments. Cells secrete and maintain extracellular matrix (ECM) which is the structural component of tissues reconstruction

Cells interact with each other and the ECM through direct contact as well as soluble signaling molecules, including cytokines, growth factors, hormones, steroids, enzymes, and other chemicals. These signals stimulate a chain reaction or cascade which alters cell behavior, both in the releasing cell itself, as well as other neighboring cells of a tissue. Mechanism of action for CAR is relevant to The anti inflammatory bio actives to control of IL1, IL6,IL10 ,IL18 also as a infra structure for cell immigration for reconstruction and healing which suggests support for local stem cells and transient amplifying local cells and promotes cell differentiation while excluding inflammatory cells and their protease activities. The composition is reflected into the controlled resorption behavior of CAR, which results in an initial integration of the particles followed by a complete resorption. While the fast resorption of some factors continuously increases the porosity of the material promoting tissue integration by allowing ingrowth of cells and blood vessels, the other component provides volume stability for an extended time period . This action assists healing tissue reconstruction, consist of different bioactive elements to make tissue reconstruction in the body and including but not limited to following bioactive elements


: Multiple bioactive factors: Stimulate growth, cell division, and accelerate the treatment and repair of various types of cartilage defects.CAR properties are *

Long term volumetric stability -

No foreign body or inflammatory reaction -

Rough surface, optimal cell adhesion, and blood absorption -

Interconnective porosity for rapid revascularization -

Safe and sterile -

Easy handling -

( Extra Cellular Matrix (ECM) composed of proteoglycan, glycosaminoglycan, glycoprotein, collagen (I, III, IV, VI, VII *
fibronectin, laminin, and elastin, and forms scaffolding to cover the tissue reconstruction

sufficient viscosity to moderate comfort of patient *


Simulation and repair of lost tissues due to the ability to differentiate and transform the immigrated stem cells *

including the tissue of the transplantation place

Full biocompatibility and lack of of immunologic reactions due to the antigenicity and immunogenicity of the CAR *

as well as DNA Diminished during the complex preparation and production process

Induction and accelerated cellular migration at the local stages due to extracellular matrix, and an appropriate substrate for healing *

Lack of local and systemic poisoning due to the absence of toxic and carcinogenic substances *

Reduce inflammation due to inhibiting pro-inflammatory cytokines and inhibiting the activity of local neutrophil chemokine, *

macrophages, and also inhibition of T cell and B cell proliferation and apoptosis

Reduce the risk of fibrosis *

Prevent excessive tissue growth by stopping abnormal vascular growth *


CAR product Directions & Aplications

Reconstruction of cartilage at osteo arthritis in phase 1,2,3 -

Increase of weak viscosity of HA in the cartilage -

Lifescell products Technology & immunity in production
 

The production line of Lifescell product is based on innovative PLACENTAL ALLOGRAFT tissue engineering regulated by biotechnology standards and protocols. After selecting the donor, firstly the medical history of the person is carefully assessed and screened with the priority of the diseases transmittable through the blood. All donor mothers are screened for chronic, infectious, neurological, autoimmune, malignant, and other environmental factors. (According to the AATB standard, these tests are repeated for the patient after the Window Period (NAT tests

Screening tests :

HIV-1 & HIV-2 Antibody

HIV Type 1 (Nucleic Acid Test *

HTLV-1 & HTLV-2 Antibody *

Hepatitis B Core Antibody *

Hepatitis B Surface Antigen *

Hepatitic C Antibody *

Hepatitic C Virus (Nucleic Acid Test *

CMV Total Antibody *

Syphilis (Serological Test *

 

( Lifescell CAR product COA ( Certificate of Analysis

Lifescell CAR product COA-1 (Copy)

The certificate of analysis data ie accredited by quality control department of lifescell biotechnology site and production line is in accordance with GMP articles and FDA regulation for good tissue practices ( 21 CFR 1270,71) also in accordance to ministry of health regulations